Efractory Acute Myeloid Leukemia (AML)

Indicated for refractory / refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation as revealed by FDA-approved testing

100 mg PO qDay with or without food until disease progression or unacceptable toxicity

In patients without disease progression or unacceptable toxicity, treat to6 months to allow time for clinical response


Dose modification
Hallucination syndrome
If discrimination syndrome is suspected, administer systemic corticosteroids; Initiate hemodynamic monitoring
Intercadibib dosing if pulmonary symptoms (eg, intubation / ventilator support) and / or renal dysfunction persist for corticosteroid initiation after> 48 hours
Reset Encenidib when signs / symptoms improve (grade 2 (mild-moderate))
Non-infectious leukocytosis (WBC> 30,000 mcL)
In accordance with standard institutional guidelines, initiate hydroxyurea
Intercadibib dose if there is no improvement of leukocytosis after the onset of hydrosaurea
Resume enasidenib 100 mg qDay when WBC <30,000 mcL
Bilirubin elevated> 3x ULN
If without continuous AST / ALT or other hepatic disorders for ed2 weeks, reduce encenedib 50 mg per day

Resume dose of encenedib 100 mg / day when basirubin height solution (x2x ULN)
Other ysis grade 3 toxicity (eg, tumor lysis syndrome)
Taking Intersidenib dosage until toxicity en grade 2 is resolved
If toxicity resolves (1 grade 1), resume encenedib at 50 mg / day; May increase to 100 mg / day
Close if ≥grade 3 occurs to think

Assess baseline blood cell count and chemistry for leukocytosis and tumor lymph syndrome prior to the initiation of ensenib; Monitor at least q2week for at least the first 3 months of treatment.

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